Invitrogen™ SLC4A4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA576715

Catalog No. PIPA576715

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Slc4a4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Slc4a4 is an electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. Moreover, Slc4a4 may regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Isoform 2: May have a higher activity than isoform 1. Mutations in the Slc4a4 gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for the Slc4a4 gene. Diseases associated with SLC4A4 include Renal Tubular Acidosis, Proximal, With Ocular Abnormalities and Proximal Renal Tubular Acidosis.

Specifications

• Antigen: SLC4A4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC4A4
• Gene Alias: AI835705; Electrogenic sodium bicarbonate cotransporter 1; electrogenic sodium bicarbonate cotransporter NBCe1 variant D; hhNMC; HNBC 1; HNBC1; KNBC; kNBC 1; kNBC1; Na(+)/HCO3(-) cotransporter; Na+HCO3- cotransporter 4; NBC; NBC 1; NBC 2; NBC1; NBC2; Nbc4; NBCE 1; NBCE1; NBCe1-A; NBC-like protein; OTTHUMP00000160355; OTTHUMP00000218884; OTTHUMP00000218885; pancreas sodium bicarbonate cotransporter; PNBC; Rnbc1; SLC4A4; SLC4A5; sodium bicarbonate cotransporter; sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas); solute carrier family 4 (anion exchanger), member 4; solute carrier family 4 (sodium bicarbonate cotransporter), member 4; solute carrier family 4 member 4; solute carrier family 4, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type; solute carrier family 4, sodium bicarbonate cotransporter, member 5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54403, 84484, 8671
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O88343, Q9JI66, Q9Y6R1
• Gene Symbols: SLC4A4
• Immunogen: Recombinant full length Human SLC4A4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG