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Invitrogen™ SLC4A10 Polyclonal Antibody
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Catalog No. PIPA5140340
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100 μL
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PIPA5140340 100 μL
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Catalog No. PIPA5140340 Supplier Invitrogen™ Supplier No. PA5140340
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: FSKGLGGQQK GHTSPCGMKQ RHEKGPPHQQ EREVDLH Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 95%.

Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. NCBE (SLC4A10) is a member of the SLC4 family of bicarbonate transporters, several of which play important roles in intracellular-pH regulation and transepithelial HCO(3)(-) transport. The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B. SLC4A10 encodes a sodium bicarbonate transporter with a brain-restricted expression pattern. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been associated with idiopathic epilepsy and other neurological symptoms. Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC4A10
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SLC4A10
Gene Accession No. Q6U841
Gene Alias NBCN2; NCBE; Sodium-Driven Chloride Bicarbonate Exchanger
Gene Symbols SLC4A10
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SLC4A10. Recombinant protein control fragment (Product #RP-109587).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57282
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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