Invitrogen™ SLC4A10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5140340

Catalog No. PIPA5140340

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: FSKGLGGQQK GHTSPCGMKQ RHEKGPPHQQ EREVDLH.

Members of the SLC4 bicarbonate transporter family are involved in solute transport and pH homeostasis. NCBE (SLC4A10) is a member of the SLC4 family of bicarbonate transporters, several of which play important roles in intracellular-pH regulation and transepithelial HCO(3)(-) transport. The SLC4A10 gene, which is highly expressed in the mammalian brain, contains two known alternative splicing units, inserts A and B. SLC4A10 encodes a sodium bicarbonate transporter with a brain-restricted expression pattern. Slc4a10 knockout (KO) mice have collapsed brain ventricles and display an increased seizure threshold, while heterozygous deletions in man have been associated with idiopathic epilepsy and other neurological symptoms. Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.

Specifications

• Antigen: SLC4A10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLC4A10
• Gene Alias: NBCN2; NCBE; Sodium-Driven Chloride Bicarbonate Exchanger
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57282
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6U841
• Gene Symbols: SLC4A10
• Immunogen: Recombinant protein corresponding to Human SLC4A10. Recombinant protein control fragment (Product #RP-109587).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG