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Invitrogen™ SLC6A8 Polyclonal Antibody
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Catalog No. PIPA542132
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100 μL
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PIPA542132 100 μL
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Catalog No. PIPA542132 Supplier Invitrogen™ Supplier No. PA542132
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Description

Rabbit Polyclonal Antibody

Peptide sequence: CDQLADRRSP VIEFWENKVL RLSGGLEVPG ALNWEVTLCL LACWVLVYFC Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%.

SLC6A8 (solute carrier family 6 member 8), also known as CT1 (creatine transporter 1), CRT or CRTR, is a 635 amino acid multi-pass plasma membrane protein that belongs to the sodium/neurotransporter (SNF) family. Expressed in a variety of tissues including kidney, skeletal muscle, heart, brain, prostate, testis and colon, SLC6A8 functions to transport creatine into and out of cells, specifically those found in brain and muscle tissue. Creatine, an organic acid, occurs naturally and is essential for supplying the energy needed for proper muscle and nerve function. Defects in the gene encoding SLC6A8 lead to cerebral creatine deficiency and are the cause of X-linked creatine deficiency syndrome, a rare disorder characterized by facial anomalies, seizures and mental retardation. Multiple isoforms of SLC6A8 exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC6A8
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene SLC6A8
Gene Accession No. P48029
Gene Alias AA589632; CCDS1; choline transporter; CHOT1; CHT1; Creat; creatine transporter; creatine transporter 1; creatine transporter SLC6A8 variant D; creatine transporter, solute carrier family 6, member 8; CRT; CRTR; CT1; CTR5; MGC87396; Na+ dependent transporter; SLC6A8; Sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter), member 8; solute carrier family 6 (neurotransmitter transporter, creatine), member 8; solute carrier family 6 member 8; solute carrier family 6, member 8
Gene Symbols SLC6A8
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human SLC6A8 (aa 200-249).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6535
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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