Invitrogen™ SLC8A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563002

Catalog No. PIPA563002

Description

Immunogen sequence: AGEDEDDGAS RIFFEPSLYH CLENCGSV Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

Sodium/calcium exchanger proteins are integral membrane proteins primarily seen in cardiac cells. In cardiac myocytes, the concentration of Ca2+ alternates between low levels during relaxation and high levels during contraction. The Na+/Ca2+ exchanger 1 (NCX1) protein mediates Ca2+ extrusion from cardiac cells during relaxation. Four NCX1 isoforms (NCX1.1, NCX1.3, NCX1.7, and NCX1.10) result from alternate splicing. NCX1 mRNA is present at high levels in the heart, with lower levels present in the brain. NCX2 is most abundantly expressed in brain, in contrast the the broader distribution of NCX1, which is also expressed in heart, kidney, lung, smooth and skeletal muscle. The difference in expression for the transporter subtypes is believed to reflect differences in their functional roles. Regulation mechanisms for these exchanger proteins have not been fully characterized.

Specifications

• Antigen: SLC8A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Slc8a2
• Gene Alias: KIAA1087; Na(+)/Ca(2+)-exchange protein 2; Na+/Ca2+-exchanging protein Nac2; NCX2; Slc8a2; sodium/calcium exchanger 2; sodium-calcium exchanger 2; solute carrier family 8 (sodium/calcium exchanger), member 2; solute carrier family 8 (sodium-calcium exchanger), member 2; solute carrier family 8 member 2; solute carrier family 8 member A2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 6543
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UPR5
• Gene Symbols: Slc8a2
• Immunogen: Recombinant protein corresponding to Human SLC8A2. Recombinant protein control fragment (Product #RP-98989).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG