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Invitrogen™ SLC9A7 Polyclonal Antibody
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Catalog No. PIPA5106748
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PIPA5106748 100 μL
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Catalog No. PIPA5106748 Supplier Invitrogen™ Supplier No. PA5106748
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SLC9A7.

Na+/H+ exchangers (NHE) of mammalian cells are plasma membrane intrinsic proteins mediating exchange of N+ and H+ ions in various tissues. The NHE catalyzes the electroneural transport of extracellular Na+ for intracellular H+. They play a major role in regulation of intracellular pH (pHi) in addition to trans-cellular absorption of Na+, cell volume regulation and possibly in cell proliferation. These primary functions of the Na+/H+ exchanger have been related to many pathophysiological states, include hypertension, organ growth and hypertrophy, regression of cancer and renal intestinal disorders. At least 7 NHE isoforms (NHE1-7) have been cloned so far. They are all similar in their primary structure and predicted to have 10-12 transmembrane domains. The C-terminal domain of NHEs are predicted to be intracellular. NHE7 (human 725 aa, chromosome Xp11.4) is ubiquitously expressed, and predominantly localizes to the trans-golgi network. NHE7 mediates the influx of Na+ or K+ in exchange for H+. It is ~70% related to NHE6 but relatively less (~25%) homologous with other NHEs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLC9A7
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SLC9A7
Gene Accession No. Q8BLV3, Q96T83
Gene Alias A530087D17Rik; hypothetical protein LOC554532; Na(+)/H(+) exchanger 7; Nhe7; NHE-7; nonselective sodium potassium/proton exchanger; SLC9A6; Slc9a7; Sodium/hydrogen exchanger 7; solute carrier family 9 (sodium/hydrogen exchanger), isoform 7; solute carrier family 9 (sodium/hydrogen exchanger), member 7; solute carrier family 9 member 7; solute carrier family 9 member A7; solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7; wu:fk03b09; zgc:101088; zgc:113878
Gene Symbols SLC9A7
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLC9A7(Accession Q96T83), corresponding to amino acid residues L535-A585.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 236727, 317170, 84679
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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