Invitrogen™ SLFN12 Polyclonal Antibody

Catalog No.	Quantity
PIPA5116929	100 μL

Catalog No. PIPA5116929 Supplier Invitrogen™ Supplier No. PA5116929

Description

Rabbit Polyclonal Antibody

Positive Samples: SH-SY5Y Immunogen sequence: DSWHVKDNRV MQLTRKEWIQ FMVEAEPKFS SSYEEVISQI NTSLPAPHSW PLLEWQRQRH HCPGLSGRIT Y.

Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.

Specifications

• Antigen: SLFN12
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 1.08 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: SLFN12
• Gene Accession No.: Q8IYM2
• Gene Alias: Schlafen family member 12; SLFN12; SLFN3
• Gene Symbols: SLFN12
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 320-390 of human SLFN12 (NP_0012759381).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55106
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG