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Invitrogen™ SLIT3 Polyclonal Antibody
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Catalog No. PIPA5104142
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PIPA5104142 100 μL
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Catalog No. PIPA5104142 Supplier Invitrogen™ Supplier No. PA5104142
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total SLIT3.

Slit guidance ligand 3 (SLIT3) is a gene located on chromosome 5q35.1, encoding a member of the SLIT family of proteins that play key roles in axon guidance and neuronal migration during development. SLIT3 functions as a secreted protein, influencing the directional growth and pathfinding of axons by interacting with its receptor, Robo, on the surface of neurons. This interaction is critical for establishing neural network architecture and maintaining proper neural connectivity. Beyond its role in the nervous system, SLIT3 is involved in processes such as angiogenesis and cell migration, impacting tissue development and repair. Dysregulation of SLIT3 expression or function has been associated with developmental abnormalities and various diseases, including cancer, where it may influence tumor cell invasion and metastasis. Research into SLIT3 continues to explore its therapeutic potential in modulating axon guidance and its implications in pathological conditions affecting both the nervous and vascular systems.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SLIT3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SLIT3
Gene Accession No. O75094, O88280, Q9WVB4
Gene Alias b2b2362.1Clo; KIAA0814; Megf5; Multiple EGF-like domains protein 5; multiple epidermal growth factor-like domains 5; multiple epidermal growth factor-like domains protein 5; SLIL2; SLIL2FLJ10764; slit guidance ligand 3; slit homolog 3; slit homolog 3 (Drosophila); slit homolog 3 protein; SLIT1; slit2; SLIT3; Slit-3; UNQ691/PRO1336
Gene Symbols SLIT3
Host Species Rabbit
Immunogen A synthesized peptide derived from human SLIT3(Accession O75094), corresponding to amino acid residues K1260-R1310.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20564, 6586, 83467
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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