Slitrk1 Rabbit anti-Human, Polyclonal, Bioss 

Rabbit Polyclonal Antibody

Manufacturer:  Bioss BS6192R

Catalog No. 50-198-7115

Description

SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette ft.s Syndrome, it is thought to play only a minor role if at all.

Specifications

• Antigen: Slitrk1
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Gene: SLITRK1
• Format: Liquid
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μL
• Storage Requirements: -20°C
• Primary or Secondary: Primary
• Gene ID (Entrez): 114798

• Gene Symbol: SLITRK1
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q96PX8
• Gene Alias: 3200001I04Rik; KIAA1910; Leucine-rich repeat-containing protein 12; LRRC12; RP11-395N17.1; SLIT and NTRK like family member 1; SLIT and NTRK-like family, member 1; SLIT and NTRK-like protein 1; slit and trk like gene 1; Slitrk1; Sltk1; TTM; UNQ233/PRO266
• Immunogen: KLH conjugated synthetic peptide derived from human Slitrk1.
• Purification Method: Protein A
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human