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Slitrk1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987115
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50-198-7115 100 μL
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Catalog No. 50-198-7115 Supplier Bioss Supplier No. BS6192R
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Description

Rabbit Polyclonal Antibody

SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette′s Syndrome, it is thought to play only a minor role if at all.

Specifications

Antigen Slitrk1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SLITRK1
Gene Accession No. Q96PX8
Gene Alias 3200001I04Rik; KIAA1910; Leucine-rich repeat-containing protein 12; LRRC12; RP11-395N17.1; SLIT and NTRK like family member 1; SLIT and NTRK-like family, member 1; SLIT and NTRK-like protein 1; slit and trk like gene 1; Slitrk1; Sltk1; TTM; UNQ233/PRO266
Gene Symbols SLITRK1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Slitrk1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114798
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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