Invitrogen™ Slo2.2 Monoclonal Antibody (N3/26), PE

Catalog No.	Quantity
PIMA545437	100 μg

Catalog No. PIMA545437

Supplier: Invitrogen™ MA545437

Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45437 was sufficient for detection of Slo2.2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 140kDa. Weak human detection.approximately Does not cross-react with KCNT2/Slo2.1/Slick.

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.

Specifications

• Antigen: Slo2.2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Microarray
• Classification: Monoclonal
• Clone: N3/26
• Concentration: 1 mg/mL
• Conjugate: PE
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene: Kcnt1
• Gene Accession No.: Q5JUK3, Q6ZPR4, Q9Z258
• Gene Alias: bA100C15.2; C030030G16Rik; EIEE14; ENFL5; KCa4.1; KCa4.1KIAA1422FLJ41282; Kcnt1; KIAA1422; Potassium channel subfamily T member 1; potassium channel subunit (Slack); potassium channel, sodium activated subfamily T, member 1; potassium channel, sodium-activated subfamily T, member 1; potassium channel, subfamily T, member 1; potassium sodium-activated channel subfamily T member 1; rSlo2; Sequence like a calcium-activated K+ channel; sequence like a calcium-activated potassium channel subunit; Slack; slo2; Slo2.2
• Gene Symbols: Kcnt1
• Host Species: Mouse
• Immunogen: Fusion protein amino acids 1168-1237 of rat Slo2.2 (Slack).
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 227632, 57582, 60444
• Target Species: Human, Mouse, Rat
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1