MilliporeSigma™ SLP76, Rabbit, Alexa Fluor 488, Polyclonal,

Catalog No.	Quantity	Conjugate
ABF1215YMI	100 μL	Alexa Fluor 488

Catalog No. ABF1215YMI Supplier MilliporeSigma™ Supplier No. ABF1215AF488

Description

Rabbit Polyclonal Antibody

Lymphocyte cytosolic protein 2 (UniProt: Q13094; also known as Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76) is encoded by the gene LCP2 (Gene ID 3937) in human. SLP-76 is a cytoplasmic adaptor phosphoprotein that contains both SH2 and SAM domains and is involved in B and T cell receptor signaling. Its amino terminus contains an acidic region that includes a PEST domain and several tyrosine residues that are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a SH2 domain at its carboxy terminal. SLP-76 can be phosphorylated on multiple tyrosine residues by the upstream kinases ZAP-70 and Lck. SLP-76 phosphorylation plays an important role in T cell-mediated IL-2 production by allowing phosphorylated Vav to bind and this complex stimulates NFAT and IL-2 gene activation after TCR engagement. SLP-76 is highly expressed in spleen, thymus, and peripheral blood leukocytes and T cells. It is expressed in B cell lines at lower levels and is not detected in fibroblast and neuroblastoma cell lines. SLP-76 is reported to play a positive role in promoting T cell development and activation as well as mast cell and platelet function. Overexpression of SLP-76 is shown to enhance IL-2 transcription after TCR signaling.

Specifications

• Antigen: SLP76
• Applications: Flow Cytometry
• Classification: Polyclonal
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Alexa Fluor 488
• Formulation: Purified rabbit polyclonal antibody Alexa Fluor™ 488 conjugate in PBS with 1.5% BSA and 0.05% Sodium Azide.
• Gene: LCP2
• Gene Accession No.: Q13094
• Host Species: Rabbit
• Immunogen: KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human SLP76.
• Purification Method: Affinity Purified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Inflammation & Immunology
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_005556
• Test Specificity: This rabbit polyclonal antibody Alexa Fluor™ 488 conjugate detected SLP76 (lymphocyte cytosolic protein 2) in Jurkat cells by flow cytometry.
• Target Species: Human
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.

For Research Use Only. Not for use in diagnostic procedures.