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Invitrogen™ SLUG Monoclonal Antibody (OTI1A6)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA526385
Description
SLUG Monoclonal Antibody for Western Blot, IHC (P), Flow
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-1. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemopoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
Specifications
SLUG | |
Monoclonal | |
1 mg/mL | |
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3 | |
O43623 | |
SNAI2 | |
Full length human recombinant protein of SNAI2 produced in E.coli. | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG1 |
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot | |
OTI1A6 | |
Unconjugated | |
SNAI2 | |
MGC10182; neural crest transcription factor Slug; Protein snail homolog 2; SLUG; slug (chicken homolog), zinc finger protein; Slug, chicken homolog; Slugh; SLUGH1; Snai2; snail family transcriptional repressor 2; snail family zinc finger 2; snail homolog 2; Snail2; snail-like protein 2; WS2D; Zinc finger protein SNAI2; zinc finger transcription factor snail 2 | |
Mouse | |
Affinity Chromatography | |
RUO | |
6591 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
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