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SMAD1 Mouse anti-Human, Clone: OTI4H4, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF809093

Encompass_Preferred

Catalog No. 50-166-9263


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ′mothers against decapentaplegic′ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Specifications

Specifications

SMAD1
Monoclonal
Unconjugated
SMAD1
BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
Mouse
Affinity Chromatography
RUO
4086
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI4H4
PBS with 8% trehalose and no preservative; pH 7.3
Q15797
SMAD1
Full length human recombit protein of human SMAD1 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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