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Invitrogen™ SMAD2 Recombinant Rabbit Monoclonal Antibody (BLR130H)

Rabbit Recombinant Monoclonal Antibody

$173.10 - $523.50

Specifications

Antigen SMAD2
Clone BLR130H
Concentration 0.5 mg/mL
Content And Storage 4°C
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
PIMA544449
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Invitrogen™
MA544449
100 μL
Each for $523.50
Only null left
Add to Cart
 
PIMA544450
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Invitrogen™
MA544450
10 μL
Each for $173.10
Only null left
Add to Cart
 
Description

Description

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

SMAD2 (MADH2, MAD2) regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. SMAD2 interacts with the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation into the nucleus is a central event in TGF beta signaling. Phosphorylation of threonine 8 in the calmodulin-binding region of the MH1 domain by extracellular signal regulated kinase 1 (ERK1) enhances SMAD2 transcriptional activity, which is negatively regulated by calmodulin. In response to the TGF-beta signal, SMAD2 is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. SMAD2 can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the SMAD2 protein have been observed.
Specifications

Specifications

SMAD2
0.5 mg/mL
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Unconjugated
Rabbit
RUO
BBS with 0.1% BSA and 0.09% sodium azide; pH 7.8-8.6
Q15796
4087
Peptide representing a region between residue 225 and 275 of Human Mothers against decapentaplegic homolog 2 (aka SMAD2).
Antibody
BLR130H
4°C
Recombinant Monoclonal
Liquid
IgG
Human
SMAD2
7120426M23Rik; EGK_09664; hMAD-2; hSMAD2; JV18; JV18-1; MAD; MAD homolog 2; Mad protein homolog; Madh2; Madr2; Mad-related protein 2; MGC22139; MGC34440; mMad2; mother against DPP homolog 2; mothers against decapentaplegic homolog 2; Mothers against decapentaplegic-like protein 2; mothers against DPP homolog 2; pSMAD2; Sma- and Mad-related protein 2; SMAD; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; Smad2; Smad-2; Smad2Deltaexon3
SMAD2
Primary
Purified
Videos
SDS
Documents

Documents

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