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SMAD4 Monoclonal Antibody (DCS-46), Invitrogen™

Catalog No. PIMA532990
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100 μg
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Catalog No. Quantity
PIMA532990 100 μg
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Catalog No. PIMA532990 Supplier Thermo Scientific Supplier No. MA532990

Description

Mouse Monoclonal Antibody

Reconstitution information: Add 1 mL of PBS buffer will yield a concentration of 100 μg/mL.

Smad4 is encoded by the Smad4 gene that is located on chromosome 18 in humans. Smad4 is also known as Smad family member 4, Sma- and Mad-related protein 4 or Mothers against decapentaplegic (MAD) homolog 4. Smad4 contains N-terminal MH1 (MAD homology 1) and C-terminal MH2 (MAD homology 2) globular domains that are involved in DNA binding and protein interactions respectively. Binding of the TGF-beta superfamily of ligands that includes Transforming Growth Factor -beta (TGF-beta) and bone morphogenetic protein (BMP) to its cognate receptor allows phosphorylation of Smad 1, 2, 3, 5 and 8 (R-Smad, Receptor Smad). This signals for heterotrimerization with Smad4 (co-Smad, co-mediator Smad) and translocation of the complex to the nucleus. Inhibitory or antagonistic Smad (I-Smad) that includes Smad 6 and 7, interact with activated R-Smads and attenuate the signaling pathway. Smad4 acts as a tumor suppressor protein by transcriptionally regulating its target genes such as Cyclin D1 (downregulation) and collagen (upregulation) that inhibit cell proliferation. Dephosphorylation regulates nuclear export and nucleocytoplasmic dynamics of Smads.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMAD4
Applications Immunocytochemistry, Western Blot
Classification Monoclonal
Clone DCS-46
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation ascites diluted in 1.2% sodium acetate with 2MG BSA and 0.01MG sodium azide
Gene SMAD4
Gene Accession No. O70437, P97471, Q13485
Gene Alias AW743858, D18Wsu70e, Deleted in Pancreatic Carcinoma 4 (DPC4), deleted in pancreatic carcinoma locus 4, deletion target in pancreatic carcinoma 4, Deletion target in pancreatic carcinoma 4 homolog, DPC4, hSMAD4, JIP, MAD (mothers against decapentaplegic Drosophila) homolog 4, MAD homolog 4, MAD homolog 4 (MADH4), Madh4, mothers against decapentaplegic homolog 4, Mothers against decapentaplegic homolog 4 (MADH4), mothers against decapentaplegic, Drosophila, homolog of, 4, mothers against DPP homolog 4, MYHRS, SMAD, SMAD 4, SMAD family member 4, SMAD, mothers against DPP homolog 4, SMAD4
Gene Symbols SMAD4
Host Species Mouse
Immunogen Recombinant human Smad4 (DPC4).
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 17128, 4089, 50554
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Lyophilized
Isotype IgG1
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