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SMARCA5 Monoclonal Antibody, Invitrogen™

Catalog No. MA523512
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50 μg
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Catalog No. Quantity
MA523512 50 μg
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Catalog No. MA523512 Supplier Thermo Scientific Supplier No. MA523512

Description

Mouse Monoclonal Antibody

Complexes containing Snf2h (SMARCA5) are capable of forming ordered nucleosome arrays on chromatin in vitro (may require intact histone H4 tails). SNF2h is also required for replication of pericentric heterochromatin in S-phase, specifically in conjunction with BAZ1A. Snf2h probably also plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Snf2h is a catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. Snf2h possesses intrinsic ATP-dependent nucleosome remodelling activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMARCA5
Applications Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Classification Monoclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% Proclin 300, 0.05% sodium azide; pH 7.4
Gene SMARCA5
Gene Accession No. O60264
Gene Alias SMARCA5, ISWI, WCRF135, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5, hSNF2H, Sucrose nonfermenting protein 2 homolog
Gene Symbols SMARCA5
Host Species Mouse
Immunogen Recombit human SNF2H (SWI/SNF-related, matrix-associated, actin-dependent) protein.
Purification Method Protein G
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8467
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG2b
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