Invitrogen™ SMARCB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120948

Catalog No. PIPA5120948

Description

Positive test controls include: SH-SY5Y, THP-1, HepG2, HeLa, Mouse testis, Rat testis. The target is usually found in the following locations: Nucleus. Immunogen sequence: LWRRLATVEE RKKIVASSHG KKTKPNTKDH GYTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST T.

The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2alpha) and Brg-1 (also designated SNF2beta) are the ATPase subunits of the mammalian SWI-SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI-SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/SNF, including the NURF (nucleosome remodeling factor).

Specifications

• Antigen: SMARCB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SMARCB1
• Gene Alias: AU020204; Baf47; BRG1-associated factor 47; BRG1-associated factor 47 (BAF47); CSS3; hSNF5; hSNFS; INI1; Integrase interactor 1 protein; malignant rhabdoid tumor suppressor; MRD15; mSNF5; PPP1R144; protein phosphatase 1, regulatory subunit 144; RDT; RTPS1; Sfh1p; SMARCB1; smarcb1a; SNF5; SNF5 homolog; SNF5/INI1; SNF5L1; Snr1; Sucrose nonfermenting yeast homolog like 1; sucrose nonfermenting, yeast, homolog-like 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 isoform a; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1a; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1-A; SWI/SNF-related matrix-associated protein; SWI10; SWNTS1; Transcription factor TYE4; Transcription regulatory protein SNF5; TYE4; Unknown (protein for MGC:138029); zgc:92517
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20587, 361825, 6598
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 2.49 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: Q12824, Q9Z0H3
• Gene Symbols: SMARCB1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 50-150 of human SMARCB1/SNF5 (NP_003064.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG