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Invitrogen™ SMC1B Polyclonal Antibody
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Catalog No. PIPA551590
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PIPA551590 100 μL
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Catalog No. PIPA551590 Supplier Invitrogen™ Supplier No. PA551590
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KSTMQILSVQ AEENCLQTVN ELMAKQQQLK DIRVTQNSSA EKVQTQIEEE RKKFLAVDRE VGKLQKEVVS IQTSLEQKRL EKHNLLLDCK VQDIEIILLS GSLDDIIEVE MGTEAESTQA TIDIYEKEEA FEIDYSSL Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 67%.

The SMC1B gene encodes a meiosis-specific subunit of the cohesin complex, which is essential for proper chromosome segregation during meiosis. It plays a critical role in sister chromatid cohesion and DNA recombination. The SMC1B protein, also known as SMC1 beta, forms a heterodimer with SMC3, which is necessary for the formation of the cohesin complex that holds sister chromatids together until anaphase. Studies have demonstrated that SMC1B is required for the activation of the spindle assembly checkpoint (SAC) during oocyte meiosis. The loss of SMC1B function leads to improper chromosome alignment and segregation, resulting in infertility due to meiotic arrest. Furthermore, the gene is expressed exclusively during meiosis, and mutations or deletions within SMC1B can cause sterility due to disruptions in meiotic progression.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMC1B
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Smc1b
Gene Accession No. Q8NDV3
Gene Alias bK268H5; bK268H5.5; mitosis-specific chromosome segregation protein like protein beta; RP1-102D24.3; SMC; SMC protein 1B; SMC1 (structural maintenance of chromosomes 1, yeast)-like 1; SMC1 structural maintenance of chromosomes 1-like 2; SMC1B; SMC-1B; SMC1BETA; SMC-1-beta; SMC1L2; structural maintenace of chromosomes 1B; structural maintenance of chromosomes 1B; structural maintenance of chromosomes protein 1B
Gene Symbols Smc1b
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SMC1B. Recombinant protein control fragment (Product #RP-91357).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27127
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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