Invitrogen™ SMC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564459

Catalog No. PIPA564459

Description

Immunogen sequence: LSRDIGRLKE TYEALLARFP NLRFAYKDPE KNWNRNCVKG LVASLISVKD TSATTALELV AGERLYNVVV DTEVTGKKLL ERGELKRRYT IIPLNKISAR CIAPETLRVA QNLVGPD Highest antigen sequence identity to the following orthologs: Mouse - 87%, Rat - 91%.

CAP-E and CAP-C (Chromosome Associated Protein-E & C) are also SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation to achieve proper segregation of genetic information during subsequent cell division. hCAP-C/hCAP-E is a component of a multiprotein complex called condensin that interacts with phosphorylation of Histone H3 resulting in the mitotic chromosome condensation. The distribution patterns of the two heterodimeric complexes in interphase nucleus indicate independent behavior of the two complexes during cell cycle. These results suggest that the two distinct complexes are involved in different aspects of mitotic chromosome organization in humar cells.

Specifications

• Antigen: SMC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SMC2
• Gene Alias: 5730502P04Rik; AI255214; AW545314; CAP E; CAPE; CAP-E; Chromosome-associated protein E; FGF-inducible protein 16; fibroblast growth factor inducible 16; Fin16; FLJ10093; hCAP-E; PRO0324; SMC protein 2; Smc2; SMC-2; SMC2 (structural maintenance of chromosomes 2, yeast)-like 1; SMC2 protein; SMC2 structural maintenance of chromosomes 2-like 1; Smc2l1; structural maintenance of chromosomes (SMC) family member, chromosome-associated protein E; structural maintenance of chromosomes 2; structural maintenance of chromosomes protein 2; XCAP-E homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10592
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O95347
• Gene Symbols: SMC2
• Immunogen: Recombinant protein corresponding to Human SMC2. Recombinant protein control fragment (Product #RP-104066).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG