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Invitrogen™ SMC5 Polyclonal Antibody
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Catalog No. PIPA530460
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100 μL
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PIPA530460 100 μL
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Catalog No. PIPA530460 Supplier Invitrogen™ Supplier No. PA530460
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1. Predicted reactivity: Mouse (80%), Rat (82%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMC5
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Smc5
Gene Accession No. Q8CG46, Q8IY18
Gene Alias hSMC5; KIAA0594; mKIAA0594; MLZ-453; mSMC5; Protein expressed in male leptotene and zygotene spermatocytes 453; SMC protein 5; Smc5; SMC-5; SMC5 structural maintenance of chromosomes 5-like 1; Smc5l1; structural maintenance of chromosomes 5; structural maintenance of chromosomes protein 5
Gene Symbols Smc5
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SMC5. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 226026, 23137
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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