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Invitrogen™ SMC6 Polyclonal Antibody

Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA560096
Description
Immunogen sequence: KEEHGKIKRE ELDVKHALSY NQRQLKELKD SKTDRLKRFG PNVPALLEAI DDAYRQGHFT YKPVGPLGAC IHLRDPELAL AIESCL Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 84%.
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). [UniProt].
Specifications
SMC6 | |
Polyclonal | |
Unconjugated | |
SMC6 | |
2810489L22Rik; 3830418C19Rik; AA990493; AU018782; AW742439; hSMC6; Kiaa4103; mKIAA4103; mSMC6; SMC protein 6; Smc6; SMC-6; SMC6 structural maintenance of chromosomes 6-like 1; SMC6L1; structural maintenance of chromosomes 6; structural maintenance of chromosomes protein 6; Structural maintenance of chromosomes protein 6-like protein | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
79677 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin) | |
0.1 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
Q96SB8 | |
SMC6 | |
Recombinant protein corresponding to Human SMC6. Recombinant protein control fragment (Product #RP-96173). | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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