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Invitrogen™ SMC6 Polyclonal Antibody
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Catalog No. PIPA560096
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100 μL
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PIPA560096 100 μL
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Catalog No. PIPA560096 Supplier Invitrogen™ Supplier No. PA560096
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: KEEHGKIKRE ELDVKHALSY NQRQLKELKD SKTDRLKRFG PNVPALLEAI DDAYRQGHFT YKPVGPLGAC IHLRDPELAL AIESCL Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 84%.

Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMC6
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene SMC6
Gene Accession No. Q96SB8
Gene Alias 2810489L22Rik; 3830418C19Rik; AA990493; AU018782; AW742439; hSMC6; Kiaa4103; mKIAA4103; mSMC6; SMC protein 6; Smc6; SMC-6; SMC6 structural maintenance of chromosomes 6-like 1; SMC6L1; structural maintenance of chromosomes 6; structural maintenance of chromosomes protein 6; Structural maintenance of chromosomes protein 6-like protein
Gene Symbols SMC6
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human SMC6. Recombinant protein control fragment (Product #RP-96173).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79677
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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