Invitrogen™ SMCR7L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA543348

Catalog No. PIPA543348

Description

Peptide sequence: GAAMLGIATL AVKRMYDRAI SAPTSPTRLS HSGKRSWEEP NWMGSPRLLN Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. [UniProt].

Specifications

• Antigen: SMCR7L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MIEF1
• Gene Alias: A230016E22; AI452372; dJ1104E15.3; HSU79252; MID51; Mief1; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa; mitochondrial dynamics protein of 51 kDa homolog; Mitochondrial elongation factor 1; Smcr7l; SMCR7-like protein; smith-Magenis syndrome chromosomal region candidate gene 7 protein-like; Smith-Magenis syndrome chromosome region, candidate 7-like
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54471
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9NQG6
• Gene Symbols: MIEF1
• Immunogen: Synthetic peptide directed towards the N-terminal of human SMCR7L.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG