Invitrogen™ SMCR7L Polyclonal Antibody

Catalog No.	Quantity
PIPA5143958	100 μg

Catalog No. PIPA5143958 Supplier Invitrogen™ Supplier No. PA5143958

Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human HT1080 whole cell, human Jurkat whole cell, human K562 whole cell, human HL-60 whole cell, human HEK293 whole cell, human U-937 whole cell, human HepG2 whole cell, rat heart tissue, rat kidney tissue, mouse kidney tissue. IHC: human renal clear cell carcinoma tissue, human rectal cancer tissue. ICC/IF: U20S cell. Flow: SiHa cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. [UniProt].

Specifications

• Antigen: SMCR7L
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and no preservative
• Gene: MIEF1
• Gene Accession No.: Q5XIS8, Q8BGV8, Q9NQG6
• Gene Alias: A230016E22; AI452372; dJ1104E15.3; HSU79252; MID51; Mief1; mitochondrial dynamic protein MID51; mitochondrial dynamic protein of 51 kDa; mitochondrial dynamic protein of 51 kDa homolog; mitochondrial dynamics protein MID51; Mitochondrial dynamics protein of 51 kDa; mitochondrial dynamics protein of 51 kDa homolog; Mitochondrial elongation factor 1; Smcr7l; SMCR7-like protein; smith-Magenis syndrome chromosomal region candidate gene 7 protein-like; Smith-Magenis syndrome chromosome region, candidate 7-like
• Gene Symbols: MIEF1
• Host Species: Rabbit
• Immunogen: E.coli-derived human MIEF1 recombinant protein (Position: S189-T463).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 239555, 315141, 54471
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG