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Invitrogen™ SMCR8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5117430

Catalog No. PIPA5117430


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Description

Description

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Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SMCR8
Polyclonal
Unconjugated
SMCR8
2310076G09Rik; AI642055; D030073L15Rik; FLJ34716; Guanine nucleotide exchange protein SMCR8; RGD1564621; SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog; Smith-Magenis syndrome chromosome region, candidate 8; Smith-Magenis syndrome chromosome region, candidate 8 homolog; Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Rabbit
Antigen Affinity Chromatography
RUO
140775, 237782, 497918
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot, Immunocytochemistry
1.65 mg/mL
PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Q3UMB5, Q8TEV9
SMCR8
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SMCR8. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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