Invitrogen™ SMN2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5119447	200 μL
PIPA5121594	20 μL

Catalog No. PIPA5119447 Supplier Invitrogen™ Supplier No. PA5119447

Description

Rabbit Polyclonal Antibody

SMN2 Polyclonal Antibody for Western Blot, IHC (P)

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.

Specifications

• Antigen: SMN2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene: SMN2
• Gene Accession No.: Q16637
• Gene Alias: BCD541; C-BCD541; Component of gems 1; GEMIN1; gemin-1; SMN; SMN1; SMN2; SMNC; SMNT; Survival motor neuron protein; Survival Of Motor Neuron 2; survival of motor neuron 2, centromeric; TDRD16B; tudor domain containing 16B; XLRS1
• Gene Symbols: SMN2
• Host Species: Rabbit
• Immunogen: Recombinant protein Survival Of Motor Neuron 2, Centromeric. The antigen corresponds to amino acid range 16-251 of the target protein.
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6607
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG