Invitrogen™ SMO Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113312

Catalog No. PIPA5113312

Description

SMO Polyclonal Antibody for Western Blot, ICC/IF, ELISA

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

Specifications

• Antigen: SMO
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SMO
• Gene Alias: bent body; bnb; E130215L21Rik; frizzled family member 11; FZD11; Gx; HGNC:11119; Protein Gx; Protein SMOH; seven transmembrane helix receptor; SMO; SMOH; smoothened; Smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled class receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 319757, 6608
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry, Western Blot
• Concentration: 2 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: P56726, Q99835
• Gene Symbols: SMO
• Immunogen: Recombinant Human Smoothened homolog protein (28-233AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov