Invitrogen™ SMO Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA572395

Catalog No. PIPA572395

Description

SMO Polyclonal Antibody for Western Blot

Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 aa, seven transmembrane G protein-coupled receptors with 4 glycosylation sites and a putative extracellular amino terminus. Smoothened activated by b-Arrestin 2 and GRK2 acts as a receptor for Shh, the Sonic hedgehog gene product, and is a positive regulator of hedgehog signaling pathway along with the smoothened inhibitor patched protein (PTCH) and regulates vertebrate developmental processes, cellular proliferation and differentiation by activating transcription factor Gli. Smoothened mutants are known to cause sporadic basal cell carcinoma of the skin. It is known to express widely in heart and brain.

Specifications

• Antigen: SMO
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SMO
• Gene Alias: bent body; bnb; E130215L21Rik; frizzled family member 11; FZD11; Gx; HGNC:11119; Protein Gx; Protein SMOH; seven transmembrane helix receptor; SMO; SMOH; smoothened; Smoothened homolog; smoothened homolog (Drosophila); smoothened, frizzled class receptor; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25273, 319757, 6608
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P56726, P97698, Q99835
• Gene Symbols: SMO
• Immunogen: region 85-116 aa.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG