Invitrogen™ SMOC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531392

Catalog No. PIPA531392

Description

Recommended positive controls: U87-MG. Predicted reactivity: Mouse (96%), Rat (95%), Xenopus laevis (84%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Secreted modular calcium-binding protein 1 (SMOC1) is a gene located on chromosome 14q24.2, encoding a member of the SPARC (Secreted Protein, Acidic, and Rich in Cysteine) family of matricellular proteins. SMOC1 is characterized by its multiple domains that facilitate calcium binding and interaction with various components of the extracellular matrix. This protein plays a crucial role in modulating cell-matrix interactions and signaling pathways involved in cellular adhesion, migration, and differentiation. SMOC1 is expressed in multiple tissues, including the eyes, limbs, and the central nervous system, and is essential for developmental processes such as angiogenesis and tissue formation. Mutations in SMOC1 have been linked to ocular conditions like anterior segment dysgenesis and microphthalmia, reflecting its significance in eye development. Current studies focus on the protein's broader implications in developmental disorders and its potential as a therapeutic target in diseases associated with extracellular matrix dysregulation.

Specifications

• Antigen: SMOC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SMOC1
• Gene Alias: 2600002F22Rik; AI848508; OAS; secreted modular calcium binding protein 1; secreted modular calcium-binding protein 1; SMOC1; SMOC-1; SPARC related modular calcium binding 1; SPARC-related gene protein; SPARC-related modular calcium binding protein 1; SPARC-related modular calcium-binding protein 1; SPARC-related protein; Srg
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64093
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.05 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: Q9H4F8
• Gene Symbols: SMOC1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SMOC1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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