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Invitrogen™ Smoothelin Polyclonal Antibody
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Catalog No. PIPA5119715
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100 μL
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PIPA5119715 100 μL
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Catalog No. PIPA5119715 Supplier Invitrogen™ Supplier No. PA5119715
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Description

Rabbit Polyclonal Antibody

Positive Control: PC-3M cell lysates, human uterine fibroids tissue. Subcellular Location: Cytoplasm, Cytoskeleton.

Smoothelin is a constituent of the smooth muscle cell (SMC) cytoskeleton. Antibodies directed to smoothelin are a useful tool to monitor SMC differentiation. Smoothelin is exclusively expressed in fully differentiated (contractile) SMCs. RNA and protein analyses reveal a broad species distribution of this protein. Cells with SMC-like characteristics, such as myofibroblasts, myoepithelial cells, and skeletal and cardiac muscle do not contain smoothelin. Confocal scanning laser microscopy of tissue sections, as well as transfection studies, show a filamentous organization of smoothelin that is different from that of desmin and vimentin. Smoothelin colocalizes with actin stress fibers. Two tissue specific isoforms have been identified: a 59 kDa isoform specific for visceral SMC; and a 100 kDa specific for vascular SMC. Human smoothelin is encoded by a single copy gene which is located on chromosome 22.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Smoothelin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene SMTN
Gene Accession No. P53814
Gene Alias FLJ35365; FLJ38597; smoothelin; smoothelin-B; smsmo; SMTN
Gene Symbols SMTN
Host Species Rabbit
Immunogen Recombinant protein within human Smoothelin aa 300-487.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6525
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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