Invitrogen™ SMURF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5111411

Catalog No. PIPA5111411

Description

Immunogen sequence: DSTGAAAGGG NCRFVESPSQ DQRLQAQRLR NPDVRGSLQT PQNRPHGHQS.

Members of the transforming growth factor-beta (TGFB) family signal through type I and type II serine/threonine-kinase receptors, which in turn activate the SMAD signaling pathway. Bone morphogenetic protein (BMP) receptors target SMAD1, SMAD5, and SMAD8, whereas receptors for activin and TGFB (e. g., ACVR1 and TGFBR1, respectively) target SMAD2 and SMAD3. Phosphorylation of these receptor-regulated SMADs induces their association with the common-partner SMAD, SMAD4. Smurf1, a HECT domain E3 ubiquitin ligase, regulates cell polarity and protrusive activity and is required to maintain the transformed morphology and motility of a tumor cell. Atypical protein kinase C-zeta (PKC2), an effector of the Cdc42/Rac1-PAR6 polarity complex, recruits Smurf1 to cellular protrusions, where it controlled the local level of RhoA. Smurf1 thus links the polarity complex to degradation of RhoA in lamellipodia and filopodia to prevent RhoA signaling during dynamic membrane movements.

Specifications

• Antigen: SMURF1
• Classification: Polyclonal
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9HCE7
• Gene Symbols: Smurf1
• Immunogen: Recombinant Protein corresonding to Human SMURF1. Recombinant protein control fragment (Product #RP-106612).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Gene: Smurf1
• Gene Alias: 4930431E10Rik; E3 ubiquitin ligase SMURF1; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF1; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF1; HECT-type E3 ubiquitin transferase SMURF2; hSMURF1; hSMURF2; KIAA1625; mKIAA1625; RGD1309707; SMAD specific E3 ubiquitin protein ligase 1; SMAD specific E3 ubiquitin protein ligase 2; Smad ubiquitination regulatory factor 1; SMAD ubiquitination regulatory factor 2; Smad-specific E3 ubiquitin ligase 1; SMAD-specific E3 ubiquitin-protein ligase 1; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF1; SMURF2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57154
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid