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Invitrogen™ SMURF2 Monoclonal Antibody (1826CT865.51.28)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA537753
Description
SMURF2 Monoclonal Antibody for Western Blot
SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Specifications
SMURF2 | |
Monoclonal | |
Unconjugated | |
Smurf2 | |
2810411E22Rik; AI558114; AI649275; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; RGD1310067; SMAD specific E3 ubiquitin protein ligase 2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2 | |
Mouse | |
Protein G | |
RUO | |
64750 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Western Blot | |
1826CT865.51.28 | |
PBS with 0.09% sodium azide; pH 7.4 | |
Q9HAU4 | |
Smurf2 | |
recombinant protein of human SMURF2. | |
200 μL | |
Primary | |
Human | |
Antibody | |
IgG1 κ |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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