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Invitrogen™ SMURF2 Monoclonal Antibody (1826CT865.51.28)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA537753

Catalog No. PIMA537753


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Description

Description

SMURF2 Monoclonal Antibody for Western Blot

SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

SMURF2
Monoclonal
Unconjugated
Smurf2
2810411E22Rik; AI558114; AI649275; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; RGD1310067; SMAD specific E3 ubiquitin protein ligase 2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2
Mouse
Protein G
RUO
64750
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1826CT865.51.28
PBS with 0.09% sodium azide; pH 7.4
Q9HAU4
Smurf2
recombinant protein of human SMURF2.
200 μL
Primary
Human
Antibody
IgG1 κ
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