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Invitrogen™ SMURF2 Monoclonal Antibody (690638)
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Catalog No. PIMA524314
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100 μg
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Catalog No. Quantity
PIMA524314 100 μg
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Catalog No. PIMA524314 Supplier Invitrogen™ Supplier No. MA524314
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Description

Mouse Monoclonal Antibody

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SMURF2
Applications Western Blot
Classification Monoclonal
Clone 690638
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Smurf2
Gene Accession No. A2A5Z6, Q9HAU4
Gene Alias 2810411E22Rik; AI558114; AI649275; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; RGD1310067; SMAD specific E3 ubiquitin protein ligase 2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2
Gene Symbols Smurf2
Host Species Mouse
Immunogen E. coli-derived recombinant human SMURF2 Met490-Glu748.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 303614, 64750, 66313
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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