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SMURF2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985867
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100 μL
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50-198-5867 100 μL
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Catalog No. 50-198-5867 Supplier Bioss Supplier No. BS4056R
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Description

Rabbit Polyclonal Antibody

SMURF2 is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. This protein interacts with SMAD1, SMAD2 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. It enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Specifications

Antigen SMURF2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Smurf2
Gene Accession No. Q9HAU4
Gene Alias 2810411E22Rik; AI558114; AI649275; E3 ubiquitin ligase SMURF2; E3 ubiquitin-protein ligase SMURF2; HECT-type E3 ubiquitin transferase SMURF2; hSMURF2; RGD1310067; SMAD specific E3 ubiquitin protein ligase 2; SMAD ubiquitination regulatory factor 2; SMAD-specific E3 ubiquitin-protein ligase 2; SMURF2
Gene Symbols Smurf2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SMURF2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64750
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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