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SN 38, Tocris Bioscience™

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Quantity:
10mg
50mg
This item is not returnable. View return policy
86639-52-3
C22H20N2O5
392.411
FJHBVJOVLFPMQE-QFIPXVFZSA-N
7-ethyl-10-hydroxycamptothecin,sn 38 lactone,7-ethyl-10-hydroxy-camptothecin,10-hydroxy-7-ethylcamptothecin,7-ethyl-10-hydroxycamptothecine,le-sn38,7-ethyl-10-hydroxy-20 s-camptothecin,captothecin, 7-ethyl-10-hydroxy,s-4,11-diethyl-4,9-dihydroxy-1h-pyrano 3',4':6,7 indolizino 1,2-b quinoline-3,14 4h,12h-dione,7-ethyl-10-hydroxy camptothecin
104842
CHEBI:8988
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O
This item is not returnable. View return policy
86639-52-3
C22H20N2O5
392.411
FJHBVJOVLFPMQE-QFIPXVFZSA-N
7-ethyl-10-hydroxycamptothecin,sn 38 lactone,7-ethyl-10-hydroxy-camptothecin,10-hydroxy-7-ethylcamptothecin,7-ethyl-10-hydroxycamptothecine,le-sn38,7-ethyl-10-hydroxy-20 s-camptothecin,captothecin, 7-ethyl-10-hydroxy,s-4,11-diethyl-4,9-dihydroxy-1h-pyrano 3',4':6,7 indolizino 1,2-b quinoline-3,14 4h,12h-dione,7-ethyl-10-hydroxy camptothecin
104842
CHEBI:8988
CCC1=C2C=C(C=CC2=NC3=C1CN4C3=CC5=C(C4=O)COC(=O)C5(CC)O)O

DNA topoisomerase I inhibitor; antitumor

Active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC 50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC 50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC 50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
Quantity 10mg
Formula Weight 392.4
Percent Purity >98%
Chemical Name or Material SN 38

Recommended Storage : Store at +4°C