Invitrogen™ SNAIL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA585493

Catalog No. PIPA585493

Description

Keep as concentrated solution. Predicted reactivity: Mouse (81%), Rat (84%), Bovine (80%). Positive Control: HeLa, Hela (1 ng/mL TGF-beta and 300 ng/mL of EGF for 2 hr), HeLa (starvation for 16 hr, 20 ng/mL TGF-beta and 300 ng/mL EGF treatment for 30 min). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Zinc finger protein SNAI1 (SNAIL)is a zinc finger transcriptional repressor which down regulates the expression of the ectodermal gene within the mesoderm and functions to form the mesoderm and neural crest. It is reported that SNAI1 acts as an important factor of tumor invasion as evidenced by its role in E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, the expression of SNAI1 and/or the homologous SNAI2 (Slug) has been associated with E-cadherin repression, local or distant metastasis, tumor recurrence, or poor prognosis in different tumor series. It is also reported that Snail 1 protein in the stromamay be anew putative prognosis marker for colon tumors.

Specifications

• Antigen: SNAIL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Snai1
• Gene Alias: AI194338; dJ710H13.1; Protein sna; protein snail homolog 1; SLUGH2; SNA; Sna protein; Sna1; SNAH; snai; SNAI1; Snail; snail 1; snail 1 homolog; snail 1 zinc finger protein; snail 1, zinc finger protein; snail family transcriptional repressor 1; snail family zinc finger 1; snail homolog 1; Snail1; Zinc finger protein SNAI1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116490, 20613, 6615
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Western Blot
• Concentration: 0.68 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: O95863, Q02085
• Gene Symbols: Snai1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human SNAI1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov