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SNF1LK2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987607
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50-198-7607 100 μL
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Catalog No. 50-198-7607 Supplier Bioss Supplier No. BS6930R
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Description

Rabbit Polyclonal Antibody

Salt-inducible kinase 2 (SIK2), like its closely related homolog SIK1, belongs AMPK subfamily of the Ser/Thr protein kinase family and negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1′alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.

Specifications

Antigen SNF1LK2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene SIK2
Gene Accession No. Q9H0K1
Gene Alias BOS_14385; G630080D20Rik; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; RGD1559698; salt induceable kinase 2; salt inducible kinase 2; Salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK2; SIK-2; SNF1-like kinase 2; Snf1lk2
Gene Symbols SIK2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human SNF1LK2/SIK2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23235
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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