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Invitrogen™ SnoN Polyclonal Antibody
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Catalog No. PIPA596446
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PIPA596446 100 μL
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Catalog No. PIPA596446 Supplier Invitrogen™ Supplier No. PA596446
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EMKEKFSMRS GKRNQSKTDA PSGMELQSWY PVIKQEGDHV SQTHSFLHPS YYLYMCDKVV APNVSLTSAV SQSKELTKTE ASKSISRQSE KAHSSGKLQK T Positive Samples: Mouse skeletal muscle, Mouse heart, Rat skeletal muscle, Rat heart.

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SnoN
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.8 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene SKIL
Gene Accession No. P12757, Q60665
Gene Alias EGK_11909; LOW QUALITY PROTEIN: ski-like protein; SKI like proto-oncogene; ski/sno related; SKIL; SKI-like; SKI-like oncogene; ski-like protein; ski-like protein-like; SKI-like proto-oncogene; Skir; ski-related oncogene; ski-related oncogene snoN; Ski-related protein; SNO; SnoA; SnoI; SnoN; v-ski sarcoma viral oncogene homolog
Gene Symbols SKIL
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SKIL (NP_0054052).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114208, 20482, 6498
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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