SnoN Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-6925	100 μL

Catalog No. 50-198-6925 Supplier Bioss Supplier No. BS5945R

Description

Rabbit Polyclonal Antibody

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.

Specifications

• Antigen: SnoN
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: SKIL
• Gene Accession No.: P12757
• Gene Alias: BOS_1080; LOW QUALITY PROTEIN: ski-like protein; SKI like proto-oncogene; ski/sno related; SKIL; SKI-like; SKI-like oncogene; Ski-like protein; SKI-like proto-oncogene; Skir; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein; Sno; SnoA; SnoI; SnoN; v-ski sarcoma viral oncogene homolog
• Gene Symbols: SKIL
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human SKIL.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 6498
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG