Invitrogen™ SNRPN Monoclonal Antibody (6F12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA549219

Catalog No. PIMA549219

Description

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Immunogen sequence is identical to the related mouse and rat sequences. Positive Control - WB: human U87 whole cell, human Caco-2 whole cell, rat brain tissue, mouse brain tissue. Flow: A549 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.

Specifications

• Antigen: SNRPN
• Classification: Monoclonal
• Concentration: 500 μg/mL
• Formulation: PBS with 4mg trehalose and 0.05mg sodium azide
• Gene Accession No.: P63162, P63163, P63164
• Gene Symbols: SNRPN
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN (11-39aa QHIDYRMRCILQDGRIFIGTFKAFDKHMN).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Western Blot
• Clone: 6F12
• Conjugate: Unconjugated
• Gene: SNRPN
• Gene Alias: 2410045I01Rik; DKFZp686C0927; DKFZp686M12165; DKFZp761I1912; DKFZp762N022; FE 294; FE 294 psi; FE294; FE294 gene for snRNP-associated polypeptide N; FE294 psi; FE294 psi pseudogene; FLJ33569; FLJ36996; FLJ39265; HCERN3; MGC29886; Peg4; PWCR; Pwcr1; RT-LI; Sm protein D; sm protein N; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA clone Sm51; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51; small nuclear ribonucleoprotein N; small nuclear ribonucleoprotein polypeptide N; small nuclear ribonucleoprotein-associated protein N; Sm-D; Smn; sm-N; snRNP-N; Snrpn; SNRPN upstream reading frame; SNURF; SNURF-SNRPN; tissue-specific splicing protein; tissue-specific-splicing protein
• Host Species: Mouse
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20646, 6638, 81781
• Content And Storage: -20°C
• Form: Lyophilized