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Invitrogen™ SNRPN Polyclonal Antibody
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Catalog No. PIPA530225
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100 μL
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PIPA530225 100 μL
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Catalog No. PIPA530225 Supplier Invitrogen™ Supplier No. PA530225
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, Jurkat, mouse heart. Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (97%), Pig (100%), Chimpanzee (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SNRPN
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene SNRPN
Gene Accession No. P63162, P63163, P63164
Gene Alias 2410045I01Rik; DKFZp686C0927; DKFZp686M12165; DKFZp761I1912; DKFZp762N022; FE 294; FE 294 psi; FE294; FE294 gene for snRNP-associated polypeptide N; FE294 psi; FE294 psi pseudogene; FLJ33569; FLJ36996; FLJ39265; HCERN3; MGC29886; Peg4; PWCR; Pwcr1; RT-LI; Sm protein D; sm protein N; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA clone Sm51; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51; small nuclear ribonucleoprotein N; small nuclear ribonucleoprotein polypeptide N; small nuclear ribonucleoprotein-associated protein N; Sm-D; Smn; sm-N; snRNP-N; Snrpn; SNRPN upstream reading frame; SNURF; SNURF-SNRPN; tissue-specific splicing protein; tissue-specific-splicing protein
Gene Symbols SNRPN
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SNRPN. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20646, 6638, 81781
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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