Invitrogen™ SNRPN Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530225

Catalog No. PIPA530225

Description

Recommended positive controls: 293T, A431, Jurkat, mouse heart. Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (97%), Pig (100%), Chimpanzee (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. The protein plays a role in pre-mRNA processing, possibly tissue-specific alternative splicing events. Although individual snRNPs are believed to recognize specific nucleic acid sequences through RNA-RNA base pairing, the specific role of this family member is unknown. The protein arises from a bicistronic transcript that also encodes a protein identified as the SNRPN upstream reading frame (SNURF). Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region. Additional splice variants have been described but sequences for the complete transcripts have not been determined. The 5' UTR of this gene has been identified as an imprinting center. Alternative splicing or deletion caused by a translocation event in this paternally-expressed region is responsible for Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure.

Specifications

• Antigen: SNRPN
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNRPN
• Gene Alias: 2410045I01Rik; DKFZp686C0927; DKFZp686M12165; DKFZp761I1912; DKFZp762N022; FE 294; FE 294 psi; FE294; FE294 gene for snRNP-associated polypeptide N; FE294 psi; FE294 psi pseudogene; FLJ33569; FLJ36996; FLJ39265; HCERN3; MGC29886; Peg4; PWCR; Pwcr1; RT-LI; Sm protein D; sm protein N; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA clone Sm51; small nuclear ribonucleoparticle-associated protein (snRNP) mRNA, clone Sm51; small nuclear ribonucleoprotein N; small nuclear ribonucleoprotein polypeptide N; small nuclear ribonucleoprotein-associated protein N; Sm-D; Smn; sm-N; snRNP-N; Snrpn; SNRPN upstream reading frame; SNURF; SNURF-SNRPN; tissue-specific splicing protein; tissue-specific-splicing protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20646, 6638, 81781
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P63162, P63163, P63164
• Gene Symbols: SNRPN
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 137 of Human SNRPN.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG