Invitrogen™ SNTB2 Monoclonal Antibody (1351)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA1745

Catalog No. MA1745

Description

MA1-745 detects alpha 1, beta 1 and beta 2 subunits of syntrophin. This antibody has been shown to react with human, mouse, rat, chicken, canine and amphibian samples. MA1-745 has been successfully used in Western blot, immunoprecipitation and immunofluorescence procedures. By Western blot, this antibody detects an ~58 kDa protein representing syntrophin from rat and mouse cell extracts. The MA1-745 immunogen is whole purified syntrophin from Torpedo californica electric organ postsynaptic membrane. Characterization studies of this antibody have demonstrated that clone 1351 is directed against an epitope within the PDZ domain of syntrophin. MA1-745, clone 1351, is seen as the gold standard for syntrophin assessment.

Syntrophins are structurally related proteins located at the neuromuscular synapse and play an important role in dystrophin associated protein (DAP) complex formation. To date there have been three distinct syntrophin isoforms discovered: alpha 1, beta 1, and beta 2. These proteins each contain a PDZ domain, a syntrophin-unique domain (SU), and three pleckstrin homology domains (PH1a,1b and 2). The PDZ domain has been shown to be responsible for binding syntrophin to nNOS and the DAP complex. This association results in localization of the nicotinic acetylcholine receptor to the cytoskeleton via the (S/T)XV C terminus.

Specifications

• Antigen: SNTB2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: Q13425, Q61235
• Gene Symbols: SNTB2
• Immunogen: Whole purified syntrophin from Torpedo californica electric organ postsynaptic membrane.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Canine, Chicken, Amphibian
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 1351
• Conjugate: Unconjugated
• Gene: SNTB2
• Gene Alias: 59 kDa dystrophin-associated protein A1 basic component 2; beta-2-syntrophin; D16S2531E; dystrophin-associated protein A1, 59kD, basic component 2; EST25263; Snt2; SNT2B2; SNT3; SNTB2; SNTL; SYN; syntrophin beta 2; syntrophin, basic 2; syntrophin, beta 2; syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2); syntrophin-3; Syntrophin-like
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 20650, 479675, 6645, 689421, 769654
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid