Invitrogen™ SNURF Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566794

Catalog No. PIPA566794

Description

Immunogen sequence: LRRTTEQHVPE VEVQVKRRRT ASLSNQECQL YPRRS Highest antigen sequence identity to the following orthologs - mouse 97%, rat 94%.

SNURF is a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame of its gene is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5' untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5' UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.

Specifications

• Antigen: SNURF
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNURF
• Gene Alias: HCERN3; Sm protein D; Sm protein N; Small nuclear ribonucleoprotein-associated protein N; Sm-D; SMN; Sm-N; snRNP-N; SNRPN; SNRPN upstream reading frame; SNRPN upstream reading frame protein; SNURF; Tissue-specific-splicing protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8926
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y675
• Gene Symbols: SNURF
• Immunogen: Recombinant Human SNURF. Recombinant protein control fragment (Product #RP-107452).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov