Invitrogen™ SNX2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA523259

Catalog No. PIPA523259

Description

SNX2 Polyclonal Antibody for Western Blot

Sorting nexin 2 (SNX2) is a gene located on human chromosome 5q23.3 that encodes a protein involved in various cellular processes, primarily associated with endosomal sorting and intracellular trafficking. SNX2, along with SNX1, forms part of the sorting nexin family characterized by the presence of a Phox (PX) domain, which binds phosphoinositides and facilitates the interaction with membrane compartments such as endosomes. Functionally, SNX2 plays roles in the retrograde transport of Shiga toxin from endosomes to the Golgi apparatus, as well as regulation of endosome-endoplasmic reticulum contact sites through interaction with VAP proteins at the ER membrane. Additionally, SNX2 is implicated in autophagy initiation during nutrient starvation by facilitating the tubulation of early endosomes toward ER sites. As a membrane-associated protein, SNX2 is essential for protein trafficking and retrieval of transmembrane proteins, thus contributing to cellular homeostasis and the dynamic remodeling of endosomal zones.

Specifications

• Antigen: SNX2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SNX2
• Gene Alias: 0610030A03Rik; CTB-36H16.2; hypothetical protein LOC509769; MGC5204; SNX2; sorting nexin 2; sorting nexin-2; Transformation-related gene 9 protein; TRG9; TRG-9
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 291464, 6643, 67804
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% BSA and 0.05% sodium azide
• Gene Accession No.: O60749, Q9CWK8
• Gene Symbols: SNX2
• Immunogen: A portion of amino acids 120-170 of human Snx2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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