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Invitrogen™ SNX2 Polyclonal Antibody
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Catalog No. PIPA530178
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100 μL
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PIPA530178 100 μL
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Catalog No. PIPA530178 Supplier Invitrogen™ Supplier No. PA530178
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, HeLa. Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (88%), Xenopus laevis (94%), Chicken (97%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Sorting nexin 2 (SNX2) is a gene located on human chromosome 5q23.3 that encodes a protein involved in various cellular processes, primarily associated with endosomal sorting and intracellular trafficking. SNX2, along with SNX1, forms part of the sorting nexin family characterized by the presence of a Phox (PX) domain, which binds phosphoinositides and facilitates the interaction with membrane compartments such as endosomes. Functionally, SNX2 plays roles in the retrograde transport of Shiga toxin from endosomes to the Golgi apparatus, as well as regulation of endosome-endoplasmic reticulum contact sites through interaction with VAP proteins at the ER membrane. Additionally, SNX2 is implicated in autophagy initiation during nutrient starvation by facilitating the tubulation of early endosomes toward ER sites. As a membrane-associated protein, SNX2 is essential for protein trafficking and retrieval of transmembrane proteins, thus contributing to cellular homeostasis and the dynamic remodeling of endosomal zones.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SNX2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.81 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene SNX2
Gene Accession No. O60749
Gene Alias 0610030A03Rik; CTB-36H16.2; hypothetical protein LOC509769; MGC5204; SNX2; sorting nexin 2; sorting nexin-2; Transformation-related gene 9 protein; TRG9; TRG-9
Gene Symbols SNX2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human SNX2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6643
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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