Invitrogen™ SNX6 Polyclonal Antibody

Catalog No.	Quantity
PIPA587586	100 μL

Catalog No. PIPA587586 Supplier Invitrogen™ Supplier No. PA587586

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MTKEEFTKMK QELEAEYLAI FKKTVAMHEV FLCRVAAHPI LRRDLNFHVF LEYNQDLSVR GKNKKEKLED FFKNMVKSAD GVIVSGVKDV DDFFEHERTF LLEYHNRVKD ASAKSDRMTR SHKSAADDYN RIGSSLYALG TQDSTDICKF FLKVSELFDK TRKIEARVSA DEDLKLSDLL KYYLRESQAA KDLLYRRSRS LVDYENANKA LDKARAKNKD VLQAETSQQL CCQKFEKISE SAKQELIDFK TRRVAAFRKN LVELAELELK HAKGNLQLLQ NCLAVLNGDT; Positive Samples: HepG2, DU145, BT-474, Mouse kidney, Mouse lung, Mouse thymus, Mouse pancreas, Rat kidney; Cellular Location: Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Early endosome, Early endosome membrane, Nucleus, Peripheral membrane protein.

SNX6 interacts with members of the transforming growth factor-beta family of receptor serine-threonine kinases. These receptors belong to two classes: type II receptors that bind ligand, and type I receptors that are subsequently recruited to transduce the signal. Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII. Of the type I receptors, SNX6 was found to interact only with inactivated TbetaRI. SNXs 1-4 also interacted with the transforming growth factor-beta receptor family, showing different receptor preferences. Conversely, SNX6 behaved similarly to the other SNX proteins in its interactions with receptor tyrosine kinases. Strong heteromeric interactions were also seen among SNX1, -2, -4, and -6, suggesting the formation in vivo of oligomeric complexes. These findings are the first evidence for the association of the SNX family of molecules with receptor serine-threonine kinases.

Specifications

• Antigen: SNX6
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.78 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: SNX6
• Gene Accession No.: Q6P8X1, Q9UNH7
• Gene Alias: 2010006G21Rik; 2610032J07Rik; 2810425K19Rik; AU018928; C85963; MSTP010; SNX6; sorting nexin 6; sorting nexin-6; Sorting nexin-6, N-terminally processed; TFAF2; TRAF4-associated factor 2; tumor necrosis factor receptor-associated factor 4(TRAF4)-associated factor 2
• Gene Symbols: SNX6
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human SNX6 (NP_0670723).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 362738, 58533, 72183
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG