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Invitrogen™ SOCS1 Polyclonal Antibody
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Catalog No. PIPA517938
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100 μg
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PIPA517938 100 μg
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Catalog No. PIPA517938 Supplier Invitrogen™ Supplier No. PA517938
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine, canine and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.

The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOCS1
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene Socs1
Gene Accession No. O15524, O35716
Gene Alias CIS1; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK2-binding protein; JAK-binding protein; Socs1; SOCS-1; SSI1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP3; TIP-3
Gene Symbols Socs1
Host Species Goat
Immunogen Synthetic peptide sequence (VLRDYLSSFPFQI) corresponding to the C-terminus amino acids of SOCS1 (aa 199-211).
Purification Method Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12703, 8651
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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