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Invitrogen™ SOCS3 Polyclonal Antibody
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Catalog No. PIPA5111637
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100 μL
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PIPA5111637 100 μL
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Catalog No. PIPA5111637 Supplier Invitrogen™ Supplier No. PA5111637
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FPSPPTEPSS EVPEQPSAQP LPGSPPRRAY YIYSGGEKIP LVLSRPLSSN VATLQHLCRK TVNGHLDSYE KVTQLPGPIR EFLDQYDAPL Highest antigen sequence indentity to the following orthologs: Rat - 91%, Mouse - 93%.

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOCS3
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Socs3
Gene Accession No. O14543
Gene Alias ATOD4; CIS3; CIS-3; Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; Ef10; EF-10; MGC71791; Protein EF-10; Socs3; Socs-3; SSI3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3
Gene Symbols Socs3
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human SOCS3. Recombinant protein control fragment (Product #RP-105454).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9021
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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