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Invitrogen™ SOCS5 Polyclonal Antibody
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Catalog No. PIPA548060
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100 μg
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PIPA548060 100 μg
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Catalog No. PIPA548060 Supplier Invitrogen™ Supplier No. PA548060
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Description

Goat Polyclonal Antibody

In direct ELISAs, less than 1% cross-reactivity with recombinant human SOCS-1, -2, -3, -6, and -7 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOCS5
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene SOCS5
Gene Accession No. O75159
Gene Alias 1810018L08Rik; CIS6; CIS-6; CISH5; CISH6; cytokine inducible SH2-containing protein 5; cytokine-inducible SH2 protein 6; Cytokine-inducible SH2-containing protein 5; KIAA0671; mKIAA0671; RGD1564914; Socs5; SOCS-5; Suppressor of cytokine signaling 5
Gene Symbols SOCS5
Host Species Goat
Immunogen E. coli-derived recombinant human SOCS-5 Met1-Lys536.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9655
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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