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Invitrogen™ SOCS6 Polyclonal Antibody
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Catalog No. PIPA597307
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100 μL
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PIPA597307 100 μL
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Catalog No. PIPA597307 Supplier Invitrogen™ Supplier No. PA597307
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR PIRSTSLRSH HYSPAPWPLR PTNSEETCIK MEVRVKALVH SSSPSPALNG VRKDFHDLQS ETTCQEQANS LKSSASHNGD LHLHLDEHVP; Positive Samples: A-549, Mouse heart, Mouse kidney.

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen SOCS6
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.55 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene SOCS6
Gene Accession No. O14544, Q9JLY0
Gene Alias 1500012M23Rik; 5830401B18Rik; AI447482; Cis4; CIS-4; Cish4; cytokine inducible SH2-containing protein 4; cytokine inducible SH2-containing protein CIS4; cytokine-inducible SH2 protein 4; HSPC060; SH2 domain containing SOCS box protein SOCS6; SOCS4; SOCS-4; Socs6; SOCS-6; SSI4; STAI4; STAT induced STAT inhibitor-4; STATI4; Suppressor of cytokine signaling 4; suppressor of cytokine signaling 6
Gene Symbols SOCS6
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human SOCS6 (NP_0042232).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54607, 9306
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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