Invitrogen™ SOCS7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA544102

Catalog No. PIPA544102

Description

Peptide sequence: LDPKALPPGL ALERTWGPAA GLEAQLAALG LGQPAGPGVK TVGGGCCPCP Sequence homology: Cow: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%.

SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Specifications

• Antigen: SOCS7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SOCS7
• Gene Alias: 2310063P06Rik; C85125; Cish7; NAP4; NAP-4; Nck, Ash and phospholipase C binding protein; nck, Ash and phospholipase C gamma-binding protein; NCKAP4; Nck-associated protein 4; SH2 domain containing SOCS box protein SOCS7; SOCS6; SOCS7; SOCS-7; suppressor of cytokine signaling 6; suppressor of cytokine signaling 7
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 30837
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O14512
• Gene Symbols: SOCS7
• Immunogen: Synthetic peptide directed towards the N-terminal of human SOCS7 (aa 35-84).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG